Report: PBPK Modeling Training

Updated: Jan 23, 2019

This first of a kind, one-week course held in November 2018 covered the principles of physiologically-based pharmacokinetic modelling and its application in pre-clinical studies, clinical drug development and the estimation of drug exposure in special populations. The course was organised by the Translational Pharmacokinetics Research Group at the Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria in collaboration with Dr Marco Siccardi of the Infection Pharmacology Group at the University of Liverpool, United Kingdom. It was designed for early-career researchers and postgraduate students whose research interest include pharmacokinetic modelling.


Participants came from a wide range of backgrounds including computational biology, pharmacology, biochemistry as well as veterinary medicine. More than 6 Universities and teaching institutions were represented.

Topics & Training Materials

Topics covered include; general principles of drug therapies, introduction to pharmacokinetics, an overview of pharmacokinetic modelling, model validation and drug-drug interactions. These were presented mainly as lectures with extensive hands-on sessions as well as journal clubs led by participants.

The Simbiology® application in MATLAB® was used to build, parameterize and validate PBPK models and the use of the graphical user interface was one of the key objectives of this training

Future Plans

Hold the course annually and offer even more advanced training.


"A very satisfying course!" - Course Participant


Over 30 scientists participated in the seminar, which was held at the Obafemi Awolowo University in Ile-Ife, Nigeria.

Report by Adeniyi Olagunju

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