This 2-part lesson reviews the basic principles of drug action via ligand receptor stimulus and response, and then expands on these concepts to dose (or concentration) response relative to clinical trial data collected during development of new drugs.
In the first part of this lesson, you will review the basic principles of drug action including: how drugs work by interacting with specific target cell receptor proteins, how the law of mass action is used to describe this process, the differences between binding and occupancy and the various models that describe receptor stimulus and response.
Learning objectives (Part 1):
Describe ligand binding as the mechanistic basis for pharmacodynamics
Review the law of mass action and its close relationship with the Emax model
Define occupancy and the stimulus-response relationship
In the second part of this lesson, you will expand on these concepts as it relates to dose (or concentration) response relative to clinical trial data collected during development of new drugs.
Learning objectives (Part 2):
Explain dose-response in the context of drug development from a pharmacological perspective
Appreciate the complexities in characterising the dose-efficacy and the dose-safety relationship during clinical drug development
Explain the difference between a modelled dose-response relationship versus comparing responses of individual doses to placebo
Presentations (Parts 1 & 2):
1.1 Please study this presentation by Nick Holford on Ligand binding
Click here to download the PDF.