Lesson Three:



In this lesson, we describe the processes of drug elimination, in particular hepatic and renal elimination.

Learning objectives:

  • Define clearance

  • Describe the factors affecting hepatic metabolism and biliary excretion

  • Describe the factors affecting renal excretion

Please note:

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-PMX Africa Team


1.1 Watch ALL of the following presentations :


You can view a pre-recorded tutorial of this lesson here: [ Video ] [ Audio ]

Additional Resources:

Please note that there are several useful resources available on the internet describing these concepts:​

Recommended books

Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G. (2007) Rang & Dale’s pharmacology. 6th edn. Pennsylvania: Churchill Livingstone.
Rowland M, Tozer TN:  Clinical Pharmacokinetics: Concepts and Applications.  4th edition, Lippincott Williams & Wilkins, Philadelphia, 2011.