Online Clinical Pharmacology & Pharmacometrics

This online course is part of a set of training activities offered by Pharmacometrics Africa and Strathmore University to support the development of pharmacometric competency and expertise in Africa and low and middle income countries.

Pharmacometrics is the science of developing and applying mathematical and statistical models to characterize, understand and predict a drug’s pharmacokinetics, pharmacodynamics and biomaker-outcome behavior. By using pharmacometrics, researchers can model the characteristics of new drugs to simulate and predict their behavior, which can then enable more efficient development of new drugs and to improve use of existing drugs.

The Clinical Pharmacology and Pharmacometrics course comprises ten lessons which cover key aspects of clinical pharmacology and mathematical modelling that underpin the principles of pharmacometrics.

Participants conduct self-study on each lesson over 1 week, and then join a live tutorial at the end of the week during which a faculty member discusses the week’s materials and any exercises that were assigned. These tutorials are recorded for off-line viewing for those who might experience difficulties with internet connectivity. All participants are assigned into small groups under the mentorship of a member of the course faculty. The course faculty are subject matter experts – they update content, design the lesson assignments and tasks, participate in online discussions, summarize the weekly discussion threads, conduct or support the weekly live tutorials, mentor participants and prepare assessments on the performance of the participants in their tutor groups.

Online learning specialists from CREATES upload all content, guide all course participants on how to use the Virtual Learning Environment, maintain communication, document course processes and offer continuous technical support throughout the course.

Application Deadline

Monday, 2 November 2020

Course Start

Monday, 16 November 2020

Lesson Plan:

  • Lesson One : Clinical Pharmacology And Pharmacometrics

  • Lesson Two: Absorption And Distribution

  • Lesson Three: Elimination

  • Lesson Four: Pharmacokinetics After Single Dose Administration

  • Lesson Five: Pharmacokinetics After Chronic Dosing

  • Lesson Six: Fundamentals Of Biostatistics

  • Lesson Seven: Pharmacology

  • Lesson Eight: Mathematical Implementation Of Pharmacokinetic Models

  • Lesson Nine: Mathematical Implementation Of Pharmacokinetic And Pharmacodynamic Models

  • Lesson Ten: Data Analysis And Regression

Acknowledgements And History
 

The materials presented in this course have been extensively updated.

The original course was previously developed and made available under creative commons principles, as open-access from Hibernia College, Dublin using grant funds from Novartis Pharma AG and the Bill & Melinda Gates Foundation. Hibernia College presented this course in 2014. A course with similar training content was presented by Karolinska Institutet, Sweden in 2015.

In May 2019, a modification of the original same course was implemented and run for the first time in Africa by the Infectious Diseases Institute, College of Health Sciences, Makerere University.

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